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Hello, I am pasture boarding a 5 horses for a women. Only for the First 80 20 to Register! I have a different doctor of course. Answer the review questions. Fish oil can be bought at many stores — if from a good company. Migraines can also be caused by magnesium deficiency.

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Read this article first before taking anything else, unless recommended by a health professional. It should also be known that all pharmaceutical drugs below contain food coloring, dyes, anti-caking agents or other compounds that should be avoided. These prenatals are very hard to find.

There are quality prenatals out there but many have only folinic acid which is not effective for those with CT mutations. Read the Prenatal Supplement Suggestions article for more information.

If you respond well, continue taking it and add in another supplement. In general, those with CT mutations have decreased ability to produce methylfolate, increased cardiovascular risk, increased risk of blood clots, increased pain and inflammation and increased chemical sensitivity. If you are not sensitive to supplements in general, then it is recommended to start with a comprehensive multivitamin and multimineral as this supports numerous biochemical functions within your body.

It also provides a fast testing ground to see if you respond well to numerous nutrients. If you do not tolerate a multivitamin well, this is a sign that you must proceed more slowly and work on healing your digestion and dietary intake and lifestyle habits first. How much methylfolate to take? This is the big question that is asked all the time.

Currently evaluating the research. To determine how much more methylfolate you need, it is best to start low and work up. This allows you to safely identify how much you tolerate without triggering very undesirable side effects. You are welcome to try them but it is highly encouraged that you proceed cautiously in order to prevent side effects from excessive methylfolate.

If you begin supplementing with methylfolate and you have inflammation unchecked, your symptoms may worsen. This is why it is critical that you are tolerating and taking probiotics, krill oil, turmeric along with improving your diet and lifestyle first. Once you have determined you respond well to the probiotics, krill oil, turmeric and vitamin E, then you may proceed to slowly adding the following.

Methylfolate Side Effects These are common despite what physicians may inform you. If side effects occur, then the amount of methylfolate you are taking needs to be taken under consideration and likely reduced. There are other steps that must be taken prior to supplementing with methylfolate if these side effects occur.

If side effects occur, taking Niacin helps bind the excessive methyl groups which are likely causing the issue. It is a good idea to have a bottle of Niacin on hand in case these symptoms occur from taking too much methylfolate. Flushing is common from taking niacin in the most active form, nicotinic acid. This is not harmful and will subside in about 20 to 30 minutes. If methylation becomes excessive, side effects will occur as noted above. This requires adjustment in your protocol.

If you feel the side effects above, it is recommended you notify your physician and have them make adjustments. General Side Effects If you are feeling improvement consistently, then you are on the right track.

These are all signs that one must listen to otherwise you are potentially increasing the circulation of toxins and not eliminating them properly. These side effects can be eliminated quite quickly through a pure vegetable and fruit juice diet for at least one day. This means producing your own juices at home via a quality juicer such as Champion Juicers. Prepare mostly vegetable juices with some fruit juices to increase the taste. Taking a capsule of Neutralize or some Niacin also helps offset many side effects.

I highly encourage that you locate a physician with training in this complicated — yet amazing — area of medicine. This is a very easy to understand article, which is a boon when so many MTHFR articles seem extremely complex.

Considering so many people suffer from some sort of MTHFR gene mutation it is important to offer information that people can digest and understand easily, very well done! I am new to your site and was just diagnosed as homozygous for the CT mutation. I am 33, but have been trying for many many years to figure out exactly what is going on with me. Since a child I have always slept at least 11 hours, but always remain fatigued. That was just the beginning of my issues.

Even to this day I get at least 10 hours of sleep but never feel rested. About 3 years ago I tried the HCG diet. Within 3 weeks I felt like a brand new person and had energy and was actually able to stay up till 10pm. While doing that diet was when I discovered I had a gluten sensitivity.

So for the past 3 years I have been GF. That has improved my stomach issues including achy joints as a child and constant bloating. I also had a colonoscopy and endoscopy to test for celiac, but everything was negative. However, I should also mention I was already GF at that point and only ate gluten for 3 weeks before the test and I am not sure if that would be enough.

I thought being GF would also help my fatigue, but it has not. So I just recently started seeing an endocrinologist. I thought maybe there was more to the food, so I have gone back on an all protein, veggie and certain fruit low GI foods no starch diet for the past few weeks. My homocysteine level came back as a There is a lot of information here and a lot I can relate to. For example, cervical dysplasia which I had many years ago and increased allergies too foods that now I have to carry an epi pen.

I also should point out that for 17 years I was on the birth control pill. I stopped that 6 months ago, but just went on the paraguard IUD since there were no horomones. Would you agree that I am going down the correct path? Do you have any recommendations since this is all new to me. FWIW, i have the same mutation and had a very bad reaction to 7 mg of folate. It seemed to increase my adrenaline, which was already high probably due to undiagnosed low cortisol.

You might want to start low and work your way up. You can buy folate over the counter starting at mcg. Hope you feel better soon. Thank you for responding. I recently had my thyroid tested. All of my numbers appeared to be in range TSH 93 , but the Dr. He thought it may reduce that and improve my other symptoms.

After one month I felt no different and there was no change in my thyroid size. Only my TSH went down to 40 something. So he increased the medicine to In regards to Adrenal Fatigue I was put on a strict diet of only protein, veggies and fruits all low GI scale for the past 3 weeks in hopes that would help.

I have stil not felt a difference. I was also tested for Hashimotos and that was negative. However, I read recently that because I have been GF for 3 years there is a chance that could have skewed the antibody test for Hashimotos. Someone actually recomended that I eat gluten again for a period of time and get retested. Do you have any history with that at all? I strongly recommend you read about the thyroid issue on this website: I found it incredibly helpful and eye-opening and bought the book as a reference.

Dear Amee, Thank you for all of the recommendations. I am happy to say that my Dr. I have definitely seen improvements in my fatigue level going way down and being more alert during the day.

However, I am writing because I have read other posts and and I noticed Dr. Ben said he recommends lower levels of Methylfolate and if you are on a higher dosage something else may be wrong. I have been taking 15mg of methylfolate for about 2 months now and feel pretty good. Is it normal for a homozygous CT individual to need these higher levels? Are there other things that I should be considering to get checked out. After being on the methylfolate my homocysteine levels decreased from 10 to 6.

One of the many tests performed by the doctors she visited was an MTHFR genetic test which identified that she has 2 copies of the CT mutation. I wonder if you have any mold in your house. I moved into a new house and months later starting having unexplained nerve pain as well as earache and muscle pain went to many doctors. One doctor asked me if I had mold in my house and, while none was visible, an air test resulted in black mold.

It turns out it was behind paneling in the basement, due to a crack in my basement wall where water was coming in. My pain went away the day after the mold was removed.

Anyway, just a thought. For the fatigue and other issues, I wonder if she has had thyroid or adrenal testing?

Migraines can also be caused by magnesium deficiency. Hoping you find answers soon. I have two very healthy boys ages 5 and 7 and both pregnancies were easy and uneventful. Both boys were born very healthy and have no health issues.

My question is, what happened? Could the interventions I had with both of them during labor epidural and pitocin have triggered the MTHFR and homocysinuria? Sadly since my diagnosis I have done very little to help my condition I did at first, but I got easily discouraged and very overwhelmed with it all.

I have actually gone the other direction and gained 15 pounds over the last twelve months and have ceased exercising. I read your response to Janet she is comp het as well and I have written down what you suggested she take as far as supplements are concerned and would like to start my own protocol too.

Since we are both comp. I have been untreated for hypothyroidism for too many years, which led to Adrenal fatigue. I eat leafy greens and sometimes juice them. I have a far infrared sauna that I try to use regularly.

I also had insomnia last night. Thank you for your feedback. I wish you were available for a consultation! Thank you for helping so many. My test says positive for one copy of the CT mutation, heterozygous for CT. My Mom has history of a large meningioma. I have serious structural and muscle pain for 26 years, migraines, ringing in head, chemical sensitivity, brain fog and recently my GI became too painful for supplements, and more. I am homozygous CT and I am avoiding folic acid, but do I have to avoid cyanocobalamin as well?

I am buying non dairy milks and they have Vitamin B 12 added to them, they do no list what kind it is. Do I assume that it is the cyanocobalamin?

Ben — how can one make a Skype or phone apt with you — I am in Canada and our medical drs no nothing about this stuff. I have double mutation for CT and none for the I have severe digestion issues, chemical sensitivities now at 49 and oral allergy syndrome. My diet is very limited since getting sick aug Nothing worked to reduce my inflammation and I started becoming sensitive to even the water I was drinking.

I had severe geographical tongue and still have patchy spots now and then even after just recently thinking to stop using fluoride toothpaste. I have tachycardia big time whenever I eat.

So where do I begin?? I am on ketotifen for the histamine and entocort steroid for the inflammation and LDN for inflammation as well. What can I do to bring my health back? Also gluten, sugar free except some coconut nectar or palm sugar in flourless peanut butter muffins for over 1 year now. I am afraid to try any supplement.

I do Epsom salt baths almost every other day for 15mins soak. I finally feel I have my candida under control. Where do I go from here??? Do you offer appts? My doctor gave me Active BFolate with mcg of methyltetrahydrofolate and mcg of Vitamin B12 methylcobalmin and told me to take 2 a day right away.

Well that was a horrible day I have to say. I went down to one a day and weathered through it and am still only taking one a day. Does this have any link to GI problems? Chest, skin, joint, and especially abdominal pains are the bane of my existence.

My doctor recommended Thorne Methyl-Guard Plus, which contains 1,mcg of methyl-B2 and mcg of methyl-folate. That had me sleeping about one hour a night and feeling like death.

He had no idea what to do next, so it was up to me to find out what was going on by experiment. I bought the individual components of the TMGP and added each one at a time. All was going well until I added the methyl-folate last.

They were taught to treat in a way that links one symptom to one disease to one test to one drug. You need to either find a doctor or alternative practitioner with detailed knowledge of MTHFR treatment. You need to do the 23andme.

HI, no one seems to be managing this site??? And if you agree, is there a glutathione precursor supplement that you recommend in particular? Precursors are the ideal way — certainly — however — it is not just the precursors needed and then the body will make glutathione. Taking liposomal glutathione is a great way to boost glutathione levels. Taking reduced glutathione via a capsule is not effective as it breaks down readily in the stomach. The liposomal glutathione has been shown to raise blood glutathione levels quite well — and quite quickly.

You want to be sure that the liposomal glutathione is non-GMO and non-soy. My company, Seeking Health, offers such a liposomal glutathione — as linked earlier in this comment. Also — do not take glutathione while pregnant.

Simply support with precursors via protein and prenatal — much safer route. I personally use the vanilla — I find that one better. I bought the Liposomal Glutathione for my six year old son who has Autism. He is always low no matter what I do with supplementing precursors. His skin clears up and he focuses so much better along with clearer and more speech while taking the Liposomal Glutathione from Seeking Health. Thank you so much Dr.

I had one other product recommended to me which contained the glutathione precursors by someone who was helped by it tremendously with regards to adrenal fatigue they are also MTHFR , but I was wary of it for the soy lecithin it contained. I was planning on starting the optimal prenatal vitamins. Do you recommend the prenatal protein powder over the vitamin capsules?

My concerns with the powder are: I know the liposomal glutathione is also made with sunflower. I realize sunflower is preferable to soy, but still undesirable.

Being Paleo is fine for many people — but following one diet extremely is likely not balanced and may cause issues. I definitely recommend the Optimal Prenatal Protein Powder over the capsules for a few reasons: You have to balance your fats — and not be extreme. I am not saying you are extreme — but making sure you are aware that we need both fats.

I think I manage to keep my Paleo lifestyle quite varied and nutritious, even while following the AIP temporarily. It is obvious to my body that gluten and grains are not a friend as evidenced by the disappearance of bloating and weight from the mere removal of these products from my diet in August. And I do agree we need balance in our fats, but I guess I just feel there is a better way to get Omega 6 than from a highly chemically processed vegetable oil.

I have chronic pain and cramping in my abdomen, back, chest, etc and no one can seem to figure out why, so I am wondering if MTHFR can cause that kind of pain. I honestly have no idea how to feel better so I think I will try to follow the protocol from teh above list thank you for making such a great and easy to understand page! Do you have any advice and can you tell me if pain like that can be related to this?

I forgot to also mention that I have fatty liver and my ALT and AST are always slightly elevated, not by much, but around above normal. Can that have anything to do with this as well? Dr Lynch, I have had a rough 9 months after taking Bcomplex 1day and bcomplex 50 for 15 days…neuropathy, pins and needles started and then severe leg muscle pain that hasnt really gone away yet. I was told to stop all supplements my neurologist said it was from the b6 and it would take a long time to heal my damaged nerves of b6 toxicity.

I ordered the active b12 and the L-5mthfr b12 it should be here this week. I started Krill oil today and low dose asprin, already take probiotics womens 90 billion I am trying to find a Dr to help me treat this around my area, but is a start? I am homozygous for ct 2 copies. Or it could be something else entirely. I also started taking AdreCorwith licorice root for my adrenals and it has the methyl Bs in it.

I have recently discovered I am homozygous for ct, although I have not, to my knowledge, ever had any related issues. I have always been healthy but have family history of various catastrophic vascular events.

Since Jan of this year I have been battling a flare up of uveitis of unknown cause, and ran across this site because I suspect that in the next treatment step my doctor will want to try methotrexate. My husband is also homozygous for ct and had a stroke at 42 which was when we found out. That was 06 and his doctor has had him on Lmethylfolate calcium, 15 mg.

I have begun taking it too with no noticeable effects, positive or negative. I am concerned about anything that could be a contributor to inflammation because of my uveitis. Our doctor seems to think the supplement is all that is necessary.

I do not supplement currently other than the methyl folate. Oldest has ADHD, middle has chronic acid reflux, and youngest has recurrent eczema outbreaks on her hands and feet of a type unusual in children. I do wonder if any of their issues could be due to the mutation. It is primarily for them that I am posting as finding info on supplements for children and proper dosage has been difficult.

Seems to me that damage is already potentially occurring by then. Recently had blood work done for my husband. The doctor we saw gave him metafolin mcg and methylcobalamin 1, mcg. He was told to take it twice a day. We would appreciate any feedback. Both our young sons and myself are getting tested. Both our boys have high functioning autism. How does epigenetics play into this gene mutation?

Is it possible with good diet and lifetstyle to not have the gene expression or do I need to assume that the gene mutation will require lifelong supplementation of methylcobalamin, methylfolate and baby aspirin? My doctor prescribed metanx with 3mg of methylfolate and 2 mg of methylcobolamin. I did not tolerate that dosage such that it made me very irritable. I now take half of Seeking Health Active B12 mcg methylfolate, mcg methylfolate and a baby aspirin daily — amongst other supplements like omega 3, vit D, COQ10, etc.

Hello Dr Ben, I have had problems with medications for most of my life, was found to have CYP disorder about 6 years ago but continued to have reactions to meds, even the smallest amounts. About 5 months ago I had reactions to everything including my thyroid medication.. The reactions continued culminating in severe reactions to almost all foods 3 weeks ago.

The only things I could tolerate were organic beef and chicken.. I started having serious welty rash, diarrhea and chills within a few days of starting the supplement. My hypothyroid is untreated now for 5 months and was also diagnosed with fibromyalgia. Thank you for your help, hoping you can give me some clarification on which supplement is best. PS, My daughter has been diagnosed with Mthfr 1 T and they took bloodwork on my grandson as he has multiple allergies.

I am a 21 year old female who has been on birth control for around four years now bad menstrual cramps. Although I am only 21, I had a stroke about three months ago.

And was having non-epileptic seizures dizziness as a child. I just learned I have this mutation last week and so all of this is new. But I want to show by example how severe this can be. Anyways, I have read a lot and I do not understand why reducing the intake of methionine is advised? Because the problem with the pathway is not being able to convert the homocysteine to methionine. And so it would seem logical that there would be lower levels of methionine and therefore we would want to increase our intake of it.

Also, is metanx not as advised? Lynch- thank you so much for this comprehensive website. I am just getting introduced to this whole world and I feel quite overwhelmed, but these resources are helping to clear things up. I am fortunate to only have a heterozygous C mutation and no C mutation.

I have done a lot of reading and have come up with two questions that would be very helpful to have you answer. Amy Yasko seems to emphasize addressing Lithium levels before supplementing with B Is that really important?

My plan is to begin with the Optimal Multivitamin and move on from there, but I would love a little input as I want to avoid the roller coaster I was on when originally put on multiple supplements by my naturopath.

I have one copy of C and have a child born with a few defects before this was discovered. A friend told me to get tested…. Turns out my six year old has the same copy too.

I am desperate to try for another child as the loss of my baby was after 3 years of IVF. Is there an alternative thinner or what do u suggest I take each day? Can I over methylate on these prenatal as the label says to take 8 a day but I feel the last two in the afternoon cause me to crash and be very aggitated at night. I await your wisdom. Your agitation at night is an indication that you may not need the amount of methylfolate in 8 pills a day of the prenatal vitamins. I find it to be a real coincidence that as soon as I took supplements for C a Prenatal I immediately got pregnant after 3 years of IVF.

Time will tell if I am on the right track taking these PreNatals and now Baby Aspirin I pray that the jigsaw pieces have finally been put together as I am not getting any younger and there is a small window here.

The conventional folate and B12 tests measure all analogues, both the active and inactive, of those B vitamins, and you may have had misleadingly high results, not reflective of your true active level of those vitamins.

I also like organic acid tests OAT as a general barometer of a number of indicators. I have this gene mutation and also have histamine issues.

I was looking at the optimal vitamin but noticed red wine something in there, is this common to cause issues in others?? I am trying to figure out which one of your methylate pills would suit me best. I show only yellow on the gene mutation for this one.

But I am also really sick with mold issues, histamine issues etc. So I am wondering if I need to look at a form of methylate? The vitamin one looked the safest.

Ben, Thank you for your website and ALL your effort and research….. I have learned so much. Through a blood test, it was identified that I have the AC mutation.

I sent in my sample and received a message from 23andme that I did not have sufficient DNA amount in my sample. I retook the test — followed the instructions precisely. The second sample came back with the same results…. Not enough sufficient DNA in the saliva sample! How do I increase my DNA in my saliva???? My Doctor is stumped…. I had the same problem, 23andme were unable to extract sufficient DNA from my saliva sample.

Some experts I have read think that this is a much more reliable method for DNA testing than the saliva sample method. Remember that the Yasko test is designed specifically for finding genetic problems related to methylation while the 23andme test is a very generalised consumer health risk test. I have recently found out that I have 2 copies of CT and I wonder what other tests I need to get the full scope of the genetics behind my health issues and now my family needs help too.

The 23andme site no longer does genetic health testing, or that is where I could have had us get comprehensive tests. You are misinformed about 23andMe. They are still doing genetic health testing.

What I have found to be very valuable is the raw genetic data that 23andMe generates. Livewello provides a similar service. If a person educates themselves, there is a wealth of information that can be learned from their raw genetic data.

I have read Dr. Lynch recommend 23andMe somewhere on these forums. What supplements would you recommend. I know she needs to proceed slowly with the methylfolate since she has exhibited side effects in the past. Thanks for your advice! My question is that I need IV Chelation to remove mercury and lead. Is there anything the Doctor should know before starting this chelation on me????

Question after background info. My chief complaints for seeking a naturopath was worsening chronic depression and nerve pain down both right arm and leg. I am hoping avoid adding any more antidepressants and ultimately get off Wellbutrin.

She started me several months ago on mg fish oil daily and IU vitamin D3. My latest D3 level was At my most recent visit she started me on several supplements at once. Magnesium Glycinate mg daily, increasing mg each week up to mg.

Mineral by PE 2 daily for 2 weeks then 4 daily. Methylcobalamin mg sublingual daily. Multi-B Complex by Integrative Therapuetics 1 twice daily. I noticed no difference in my symptoms the first week or so. I had been fatigued before and continued to be fatigued. Then my fatigue started to get worse. I was feeling spacy, off balance, my thinking was sluggish and my energy was sapped.

I then had my follow up appointment with her. My crushing fatigue had lifted the tiniest amount with the folate switch. We discussed my concern with the Kidney pain I had started to experience that was getting worse. The urine pH was off but everything came back normal on the labs. She had me increase the methylfolate to 2 daily for I week to then increase to 3 daily.

Lots of reading by me on the internet and I changed from placing the B under my tongue to inside my cheek. I got an ah-ha moment when the crushing fatigue began not even 20 minutes later.

That was 5 days ago. I stopped all B vitamins on that day and I am back to me pre-supplement self. My question is this. The video implies that I should start back at zero supplements and start fresh. But at the end of the treatment cascade he mentions that we of course should have vitamin D, Krill Oil, etc in place also. The video says to start with methyl cobalamin but the website says to start with Optimal Multivitamin first for a heterogygous mutation.

Which should I do first? FYI — thinking of replacing my b complex and mineral complex with Optimal Multivitamin. Thinking of adding mixed vitamin E IU daily. I am going to be working on a laypersons course soon with some basic information. Currently, the information I have is pretty complex — at http: You may want to try B Minus — this is a B complex without any B12 or folate.

Vitamin C can be quite useful along with liposomal glutathione but start very low at first — few drops at a time and increase slowly. Ok, so b minus along with trace minerals instead of the Optimal Multivitamin. Already have magnesium on board. But what about the timing of adding the B supplements. I found the explanations on the heartfixer website regarding the different enzymatic pathways to be helpful.

I was just confused by the conflicting information. I realize this is an ever evolving protocol. However his protocol starts them separately. I think he did this to avoid trapping, but he then says that this is no longer the case.

For the past 14 yrs. Some anti-depressant have worked for short periods of time, but I have struggled more and more as the years pass by. About a year ago I found a Naturopathic physician. Finally I see hope that I can reverse the downward spiral and find life livable.

I am only just beginning on this path and hope the doctors I have at my disposal will be open to learning and applying all that you have discovered. I just have been diagnosed for ac heterozygous mutant, I had 2 miscarriages, 1DVT , 2 pulmonary embolisms and have psoriasis and hypothyroidism also. It has many of the components that you discuss in your supplementation protocols but what do you think about taking them at the same time in one supplement?

It depends on the person. For some, it is great -for others — not so great. Have to give it a try and see how you do. Start low with the amount and work up.

I just watched your presentation on the Thyroid Summit, Dr. I am heterozygous CT. I currently take a prenatal by Thorne with 1mg methylfolate in three capsules. I take two capsules. I feel fine—not extremely different from before switching prenatals, but I did notice that I get a small migraine much less severe and shorter than I usually get each month since starting the methyfolate.

I notice heart palpitations each day too. Nothing major but there. I also have hashimotos and am on the autoimmune paleo protocol to help heal my thyroid—which is working! I am very healthy and active, but also PCOS, which could be caused from the hashimotos. Anyway, I try to consume a lot of turmeric. I notice that I crave it. I also started introducing liver into my diet. There is something in it that I need.

Do you think I need to either reduce the methylfolate I am taking or take another supplement to counter act this? If so, which one? Thanks for your time! I am so glad to have found your website! I am inclined to start with the active B12 as I am not chemical sensitive. Based on other blood work I am wondering how I should modify the basic protocol. The directly relevant additional results are:.

Most of this supplementation resulted from my concern over elevated liver enzymes in previous tests and a long term issues with focus and energy. Interestingly I have focused my attention on liver health and neurotransmitter support. It turns out this was the right track but I did not know about the potential genetic underlying cause.

I am a 34 year old white male, 30lbs overweight, a grad student so I do a lot of sitting while researching. Given that data, especially my homocytsteine and B12 levels how would you recommend I approach the protocol?

I also take vitamin D and Primal Defense Ultra probiotic. I have been strictly gluten free for around 8 years, I am dairy intolerant so occasionally have sheep or goat dairy only, I rarely eat processed food. Thanks in advance, Danielle. My doctor is always booked for months, and overbooked, so never has time to talk in detail about the questions that I wonder about every day.

My brother, with the same mutation, was given 15mg of Deplin, so before I even saw my doctor, I started taking Methyllife L-methylfolate 5mg, increasing slowly to three times a day. When I went to my doctor, he gave me a B Complex vitamin with methylfolate mcg to take twice a day. I thought it was weird that it was such a huge difference in dosage compared to what my brother was taking, and also a huge difference from what I then was taking on my own before seeing an endocrinologist.

Which things do you think are most important? I also have very bad stomach issues, and my doctor tested me for Celiac disease which came back as negative. My lab tests came back saying that I was on the borderline of having hypothyroidism and elevated homocysteine. I really would like to know one way or the other about both of these, and get them treated if there is even a chance that it could make me feel better. Thank you for providing this most valuable information.

My daughter is suffering greatly from this condition and has not been able to get help from doctors in our area. She reads everything she can find on this condition especially the articles you write.

She already does some of the things you listed and will immediately start doing many of the others. You are helping so many people by offering your information and products. Thank you, thank you, thank you!! Ben, I would like to try your Optimal Multi-Vitamin because I am homozygous ct along with a bunch of other mutation of course. Since these are not an IgE allergy do you think it would be ok for me to take the Optimal Multi anyway?

I wanted to thank you, Dr. This website and your videos and podcasts have helped me and my naturopath to straighten out my supplements and get my health in much better shape. Your advice and knowledge and down to earth style have helped. Ben, I have one copy of each and Do you recommend anything else to help sustain this pregnancy. Thank you for any insight.

Hi David, thanks for your interest. Years ago, in my experimentation with vitamins, I had started taking B12, and since I do a lot of research always, into my supplements, I eventually started ordering methyl B12 because I had read it was better absorbed.

One day I took 5 and felt so incredibly better that it was like night and day. It was some time before I started taking folinic acid, but again I had read that the folate form was better than the folic acid form. My testing for that was very recent, and now I know so much more than I did before.

I take about 4 a day at mcg each Jarrow , and I also still take folinic acid, about 4 a day at mcg each. Ok, so here goes: I used to take 8 folinic acid a day mcg , and 24 methyl B12 a day mcg. Every time I took my vitamins 4 times a day I would have to take 6 methyl B12, mcg. Every time I tried to cut it down, I would get a very sore tongue, and my fatigue would be worse. Then I started experimenting with the folinic acid, and that got up to as many as 30 pills a day of the mcg pills.

But it leveled the interaction between the two, I think, because I felt better, and I was able to back off on the B12 somewhat. I really appreciated Dr. I now understand that some of my symptoms were overmethylation I feel embarrassed to say!

So this part of the puzzle has me very, very happy. The Betaine is absolutely critical for me. My digestion really depends on it. I do not eat any grains at all, or carbs, or dairy, or sugar. I have to be careful about the amount of fructose I eat. Carbs and dairy make me dizzy. I also use quite a bit of l-glutamine for my stomach, and a little creatine. I used to eat a lot of nuts, but the phytates seem to affect my digestion negatively, so I only eat them occasionally now.

Lynch has given, and all of you here, has helped a lot. And thanks for reading all this! Marcia, Thank you so much for your detailed information. I have a question. Did you originally start with methylcobalamin B12 to see how it worked and then add in the methyl folate? I was working with a couple of practitioners.

In the end I was on about 25 supplements and feeling worse everyday. A couple weeks ago I stopped everything. What supplements do you recommend he start with? Thank you for all the information you have provided on your website. Hi Dr Ben, I also have pyroluria, as well as mthfr… I must avoid copper in supplements.

I have 2copies of , and one of I have zero interest in food and hate cooking. I am so weary of it all, but persevere. I take all my supplements seperately, and the bottles are taking over the house. Any multis that you are aware of with no copper? Gloria, Not sure if anyone got back to you on this. Both brands contain the 2 forms of B6 recommended for pyroluria as well as methylfolate and methylB The Seeking Health one also has adenosylB Can you provide links for any pages you found useful?

Does he still believe one should introduce methylcobalamin before methylfolate? Any help would be appreciated. However there is definitely a Dr Ben Lynch video on YouTube where he says that he needs to revise his protocol as he now suggests to take them together.

I think the video that mentions this also features Ameer Rosic but I could be wrong on that as there are 6 Dr Ben videos that I know of totaling about 9hrs! If you do find out then please do let us all know as I am currently working on improving my gut, diet and liver and then finally I will once again try the B12 and Folate.

I actually saw your post. I wish we knew which video to look at. I was wanting to watch one of his videos where you had to pay to watch. I am seeing a functional nutritionist who is extremely knowledgeable and has healed herself of almost exactly the same things that I have.

Though she can order functional tests, she had me see a functional MD so he could order further tests. I had some different ones also, but much the same. What happened was that the more supplements I was adding, the worse I felt. Until the point where I felt so toxic, and had so much body ache in my neck, back and shoulders, and strange headaches that I stopped everything.

Within a day or two I felt much better. I am now introducing a new supplement every two days. If I feel ok, I add another one. A piece of the puzzle that I think was missing is that I have to heal my gut first. I was at the Institute of Functional Medicines conference in Feb and spoke at length to one of their nutritional consultants.

It has some amazing products in it. I also ordered methylcobalamin lozenges from them. I expect there hundreds if not thousands of people in the same boat. There are a lot of similarities between your path and my own.

After 5 days I stopped as the pounding 24hr headaches were no longer bearable. Since then after watching videos by Dr Ben, Neil Rawlins and Richard van Konynenburg I have a much better understanding of how the gut is linked to all of this. Even today I have just had to cut out the 4 most recent ones and I will try reintroducing them.

Some things have helped but as you say you need to introduce things slowly and one at at time. But every now and then I slip up and have to back track. Usually with a bad headache. One thought my ND had is that I have systemic Candida. So I have cut ALL sugars even fruit , grains, dairy, pork, and starchy veg. I can tell you it has been tough….

I pretty much went for 3 week straight with no brain fog, confusion or loss of balance. SO there is absolutely a link to diet. I thought it would take ages to look through all my MTHFR videos but as luck has it I found it in the first 5 minutes. The YouTube video you want is https: Also, though I rarely if ever eat corn, as it used to give me headaches, a couple weeks ago my kids had some non GMO popcorn.

I have to say I ate quite a bit for a couple of days consecutively and I never got a headache. As for the other info, I am now working with an amazing naturopath who went to the methylation conference last year. Everyone in her office did. When I showed her my supps 27 bottles I brought into the office , I did have a bottle of sublingual B I do believe she said to start with that.

But my multi vitamin that she likes Nutrient without iron from Pure Encapsulations does have some of both Bs. Again, let me know if you decide to do the NuMedica line as I have a bit more info about how to take it. Wow what a great website! My daughter has had years of pain, stomach issues, chemical sensitivities, food sensitivities, etc as have I.

Thanks for all of this information so I can try and help her more. When I began taking methylcobalamin, with supplements, I knew nothing about any of this, and was trying B12 out after my naturopath said it would help with cortisol problems I thought I was having problems from stress.

When I happened to take several of the mg supplements later I switched to mg , I felt so much better, with much better energy, that it started me on a long road of experimentation, but unfortunately I wound up using very high quantities of methylcobalamin for quite some time, and became quite overmethylated I now know. As for the folate, the folate that I was getting was coming from B complex pills that had folic acid in them.

Eventually I read about folate being better than folic acid and I switched to folinic acid, not really knowing about methylfolate at all. I took quite a bit of folinic acid, for quite a long time and recently had increased the amount of folinic acid to very high amounts and that was helping with the overmethylation somewhat, because I was taking too much methylcobalamin, and it was more in balance.

I started experimenting, and added methylfolate into my supplements, backed off on the folinic acid, and backed off on the methylcobalamin. Had to go down to the bank, I never did remember it.

My poor brain is so sensitive. I think I really need the methylcobalamin to think. My brain fog and dizziness can be a constant companion sometime, and all day long I struggle with it, and take my supplements partially guided by it, as the day goes on. The two important supplements for it are zinc and B6. If I take zinc citrate and B6 regular B6 not P5P , periodically through the day when I feel the brain fog and dizziness, it seems to help.

My anxiety level has decreased since I started taking the zinc and B6 during the day. Anxiety is another symptom of pyroluria. The l-glutamin, d-ribose and creatine help my energy level and clarity of mind, too, and so does the selenium I take. I take quite a bit of magnesium malate, and calcium. I have a lot of trouble with fructose malabsorption, and cannot eat dairy or gluten or really any carbs.

Everybody likes to have some kind of treat! I love to have people to talk to about all this. I spend a lot of time and effort and money! I take my B complex, which has methylcobalamin and methylfolate, I take two or three or four methylfolate a day, and about three methylcobalamin in a mcg dosage.

Thank you for all the great work you are doing and information you are providing. I am homozygous for the C T allele and follow your basic protocol with some tweaking. I am postmenapausal and have been getting estrogen and testosterone slow release pellets implanted for 8 yrs now. I also take bio identical, compounded progesterone nightly.

When you say no birth control or oral hormone estrogen you mean because they are processed through the stomach and liver right? Is it ok to continue taking them the way I do? That means that scientists say that what they have observed will always be true. It is stated as fact. It was believed that the atom was the smallest thing in the universe.

It was called fact. Then someone figured out how to split it. The point is that science only really tells us what has been observed. It just states what is observed and measured in the world around us.

Why am I making sure you understand this? Because who was there to observe the creation of the universe? It takes what it observes in the world today and makes hypotheses, guesses, about the creation of the world. Until pretty recently most scientists were Christians.

Never let anyone make you feel stupid for believing God created the world. The Bible contains all truth. You never have to be afraid to believe the truth in the Bible. Say, we measure stars at being billions of light years away. That means, in order for us to see its light, that light would have had to be traveling for billions of years to reach us.

Well, a Christian mathematician and scientist has shown how it could appear that way and still only be less than ten thousand years away. No one has yet been able to dispute the math he used to show it. There are some that say carbon dating shows that there are bones that are millions of years old.

These are articles for adults. The first is much easier to read than the second, but if you or your parents are interested, please go ahead and read them. I just want to show you that there are scientists that believe the earth is young. I personally know a scientist, a physicist with a PhD, who has studied the topic and believes the earth to be less than 10, years old.

It will always prove to be true in the end. God is Truth and cannot lie! You can trust His Word. Are you finished with all of your work? Click on arcade to begin. The Story of the Romans. You are going to need dirt and seeds. I have always found beans the easiest to grow. Just buy the beans you eat. But I would recommend choosing younger rather than older ones.

You are making masks. Or maybe you could tape them to sun glasses? You have to decide if it would encourage or scare your children. It talks about them being tortured, burned at the stake, fed to lions, etc. Play, just a little. Touch every red square. Wanna hear a joke? Help the cat find fish for lunch. Are you finished with all of your work for today?

Then play the space and arrows game! The curriculum does not teach evolution. I believe in a literal 6-day creation. Some websites that the kids go to do mention millions of years, and I point it out and say something about it each time to varying degrees.

You can read what I wrote on Day 1 of this page from the ancient history and biology courses to see how I discuss it with the kids. Please review the FAQs and contact us if you find a problem with a link. The list of names shows the generations from Abraham to David to Jesus. Tell to a parent the story of Joseph that you read today.

History Did you know that the Bible is considered to be one of the most accurate history books in the world? What is the difference between history and pre-history? We can read about Adam and Eve living in the garden and speaking with God. Science I want to teach you something about science.

Here are a lot more different kinds of nature sounds if you want more. Mix together some different sounds. Jesus is anointed by the Holy Spirit, choosing Him as the leader of Israel as was prophesied hundreds of years before by Micah. What prophecies are fulfilled in this chapter? Do you belong to Christ and serve His people alongside Him? Click the arrow to turn the pages. Before you can use this site, you will need to register. This is a site where you can use your junk email and password.

Make sure you tell the site to remember you. Our book does not teach that God created the world in six days. It will speak of millions of years. They say they changed little by little until they became human.

My personal opinion is that it is senseless. I call it a hypothesis because it has never been observed happening and therefore cannot be called scientific theory, let alone fact. You may click on the link to watch the vimeo video on the introduction to life. Answer the review questions Go to the end and read the questions first. That way you can be looking for the answers while you read.

It will make it easier for you if you will just take an extra minute to look at the questions before the reading. They need to show that they have repented and turned away from sin. Jesus gave us the example and we are to follow in His footsteps and be baptized as well.

It marks the beginning of our life of following Jesus. Baptism represents our dying to self and resurrecting to our life in Christ. Part of Galatians 2: Actually, it says that Jesus will baptize us with Holy Spirit and with fire. Some people think they are one and the same since the Holy Spirit came down on the church appearing as fire. Read through this timeline of Ancient Egypt.

Now look at this Bible timeline. Remember the biggest number goes to the left! Answer review questions What makes skin an organ? Be on the lookout for drawings on the cave walls. Be on the lookout this week. Find a rock this week that you could paint on. Also, collect a twig or something to use as a brush as well as flowers, berries, mud…to use as paint. Jesus and Satan both use Scripture. Satan can use Scripture but twist it or use it out of context.

Not everyone using Bible verses is telling you the truth. Even the KKK used the Bible. Memorizing verses puts a sword in your hand to help you fight off temptation. In the second part of the chapter, what does Jesus preach?

They left their jobs and they left their families. They had to trust God to take care of them and their families. If God calls you to leave your work, He will provide for you. Our family has seen it happen! Click on both pyramid links.

Take a look inside the pyramids. Look at the first twelve verses. These are called the Beatitudes. Are you any of these things? What are you not? It should be your desire to be like Christ who is all of these things. And being like Christ comes with persecution.

Do you think you could rejoice that you are persecuted? What do you think is the most surprising sentence in this chapter? Write what it says and why it is shocking. Click on the keyboard icon to show more choices. Read it and then choose your age from the list and try it!

If you like, you can try and write your name in hieroglyphs. Ask your mom what you can scrub or find a stubborn stain. Scrub it until your arm hurts and then scrub another minute more. What are verses about? In the end you will be richer if you give. And as a bonus, we will be rich in faith. This is selfish self-centered thinking.

We are to love others as we love ourselves. There are some people who give away half of the money they make so that they can obey the Scripture to love others as they love themselves. Read the fun facts and then take the quiz bottom left. Here are notebooking pages to choose from if you like. Use AdBlock Plus or have a parent load the page. Read the names of the muscles. Use the scanner to find the muscle named; it will be a different color.

Repeat until you can click on all of the muscles. Have a parent load the page and decide about the ads. One of the earliest man-made instruments must have been some sort of drum.

Click on play and use your keyboard. Read the first four sections. Then jump down to the facts at the end. You can skip over or read if you like about the papyrus scrolls they have found. Answer the review questions. Follow the story, answer the questions, embalm the dead guy, yuck!

The embalming is a puzzle to solve. First figure out which four organs need to be saved. Then use the clues on the god cards to figure out which one goes where. They give you all the hints you need. Some you can do just by length. The others you need to use the last note in the resource section. Take the tour of the skeletal system. Click in the bottom right corner to move on. Use this alternate link. Then you can label the skeleton.

If you found natural paint and brush, use those. Paint something that someone long ago could have painted. Write a page about life in ancient Egypt based on what you just read. Start your page with an introductory sentence that tells what you are going to be writing about. Then take the quiz. Here are some maps you could use to help you. Some of those maps do not work.

Play Senet , the oldest board game in the world. Stop at the review questions and answer First play the virtual log drum.

Explain to a parent how it can make two different sounds. Then click on the links at the bottom. Play the Unifix Cube Drum Machine. Fill in at least one thing for each category and place some date to go with it. Fill in whatever else you deem significant to add. Work at a computer with a printer if you are typing on the timeline. Here is clip art you can put on your page. Or you could draw and write. Trace your hand and make the hand picture.

Draw a horse and man for hunt scene. Report your scores to your parents. Choose a game from the review games page. If this is your first year using the curriculum, you might want to choose word invasion or juice bar, or machines.

This is from BC. Write the story of a doughnut being eaten and digested. You can write it as the doughnut speaking. OR, draw a diagram of its route and add labels telling what happens at each point.

While some of those drums were modern, I figured a drum was probably the earliest instrument. But I thought of another. Click on the play triangle and nothing else. The voice is another instrument the Lord made along with all the songs of nature. Write a paragraph about what you learned from this reading. Make sure you save it! Watch a video on one of the ancient 7 wonders of the world, the hanging gardens of Babylon.

While you watch, draw a picture of the hanging gardens. When you are finished, show your drawing to your parents and explain why it was a marvel. Fill in the muscles. Whistles are an old type of instrument. You can see a colonial times version of it on this game.

Use a large black marker if you have it or black paint and thick brush. At the bottom of each one, write the English, its definition and the quote. You can tape on paper towel rolls at each end if you want to make a scroll. You should put a title on the page as well. Read through all the pages. Take your pulse resting and then after running around. If so, then you can play this game. Listen for the harp. Read the lyrics ; sing the song. This is ancient China history in song. Make sure you check your answers and go back and look at what you got wrong and learn the right answer.

Click on the video. To make a square sheet of paper, fold down the top corner of a piece of paper to line up with the far side to make a triangle. Now you have a square to begin with. Write a couple of observations about each. Look at the images and write what you observe. See what you can learn from the quiz. Three choices of what to do today. Choose one, two or all three. Write a story about your trip to ancient China. The first link is a page of Chinese characters to write.

You can write them on paper or online with the second link. What type of instrument is being played? Or, if you want, you could use notebooking pages and add more if you need to Ancient Maya Notebooking pages — about halfway down the page. Watch the video at the top of the page about the Maya. Then scroll down the page and read about where they were located. See where they lived on a map. You need to add information to your project every day.

Watch this quick video on inspiration. Read the steps and then play Match. Build a model of the lungs. You can do this together with an L student. Demonstrate your model and explain it. Read the sections on the Early and Classic Maya. Add important and interesting information to your project today. Read about the Mayan calendar. Find your birthday in the Mayan calendar. Make observations from these two chapters. On the one side write things about man, not just Noah but people in general.

On the other side write things about God. Then in the middle write what observations you can make from these two chapters about the relationship between God and man. Listen to ancient Mayan music. What types of instruments do you think you hear in each? Say all of your memory verses so far this year. Scroll down to read the end part. How are Lot and Abram related? The first 2 questions are not labeled. What does God promise Abram? He honors the Lord.

He gives honor to God instead of becoming proud, thinking look how great I will be when all of this land is mine. What was the name of the priest of the God most high? Melchizedek What did Abram give him? Click through and read all five pages. Make a clay pot like the Mayans. You have to let it dry several days first. If you can, take a picture of your pot and insert it into a document. Add your name, date and explanation.

Add it to your portfolio. What promise does God make to Abraham about his descendants? Verse 6 is the first time we see that we can be saved by faith. Abram believes and God calls it righteousness, doing what is right. Do you know when the prophecy in verses 13 and 14 come true? What is the covenant that God makes with Abram at the end of the chapter? Look at the maps in order. Notice the Dead Sea. Go back and click on map 2 and find the sea in the middle.

You can find the Euphrates on this map. Israel is often in the news. There are always disputes over the land of Israel. Who are they fighting with over the land? You will read a lot in the Bible about the Israelites and the Philistines fighting over the land. Today in English they are called Palestinians. In other languages, though, they are called Philistines.

God made this covenant, a sacred promise, with Abram before there even was such a thing as Israelites. Listen to the creation story as told by the Maya. Did you notice the destruction by flood? Many cultures have a creation and flood story. This shows how ancient these stories are and have been passed down and moved around to have reached opposing sides of the globe even in ancient times.

Of course stories change and are adapted as they are passed around. Stop at the review questions and answer them. Add your name, the date, and the title of the chapter you read. Give this paper to your parents to add to your portfolio. What are the new names given them?

An extension of the Easy Peasy All-in-One Homeschool