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Leptin has thus emerged as a candidate to link obesity and osteoarthritis and serves as an apparent objective as a nutritional treatment for osteoarthritis. The placenta produces leptin. Immunoreactive leptin has been found in human breast milk; and leptin from mother's milk has been found in the blood of suckling infant animals. Similar to what is observed in chronic inflammation, chronically elevated leptin levels are associated with obesity, overeating, and inflammation-related diseases, including hypertension , metabolic syndrome , and cardiovascular disease. Caro 's laboratory provided evidence that the mutations in the mouse ob gene did not occur in humans. Thyroid hormones T 3 T 4 Calcitonin Thyroid axis.

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