When metal instruments were finally used to any extent, the act of cauterizing accompanied it. Defects in the transport of chloride, sodium, and other ions result in unusually high levels of ions inside the cells of the lungs. In some procedures, the blade was heated until it glowed red, and then used to make incisions. For an organism to function normally and effectively, it is necessary that the biochemical processes of its tissues operate smoothly and conjointly in a stable setting. She became well immediately. A novel herbal formulation for joint health and support Our Joint Care kit is a novel herbal formulation for joint health and support that helps in Prevent weakening of bones, joint degeneration, arthritis and muscle weakness Provides strength to ligaments and tendons Prevents fracture of bones Dosage: Hypocupremia induced by zinc therapy in adults.
e-Library of Evidence for Nutrition Actions (eLENA)
States with lowest percentage of under-nutrition include Mizoram, Sikkim, Manipur, Kerala, Punjab, and Goa, although the rate is still considerably higher than that of developed nations. Punjab, Kerala, and Delhi face the highest rate of overweight and obese individuals. Studies show that individuals belonging to Hindu or Muslim backgrounds in India tend to be more malnourished than those from Christian, Sikh or Jain backgrounds.
On an individual level, a person can be obese, yet lack enough nutrients for proper nutrition. Women with higher economic means in urban areas fall into obese and overnourished category, while conversely lower income women in rural areas are underweight and undernourished.
Access to healthy and nutritious foods within India has been increasingly replaced by a large supply of high-calorie, low-nutrient foods. A strong connection has been found with malnutrition and domestic violence, in particular high levels of anemia and undernutrition.
In moments of high stress, free radicals are produced which attack healthy red blood cells, therefore lowering hemoglobin blood levels and producing anemic malnutrition. The Government of India has launched several programs to converge the growing rate of under nutrition children.
The Indian government started midday meal scheme on 15 August It serves millions of children with fresh cooked meals in almost all the government run schools or schools aided by the government fund. These programmes are conducted with part subsidies from the government and partly with donations from individuals and corporations. The meals served by Food for Life Annamrita and Akshaya Patra complies with the nutritional norms given by the government of India and aims to eradicate malnutrition among children in India.
Food for Life Annamrita is the premier affiliate of Food for Life Global the world's largest free food relief network, with projects in over 60 countries. ICDS has been instrumental in improving the health of mothers and children under age 6 by providing health and nutrition education, health services, supplementary food, and pre-school education.
ICDS is run by India's central government via the Ministry of Women and Child Development, targeting rural, urban and tribal populations and has reached over 70 million young children and 16 million pregnant and lactating mothers. The challenge for these programs and schemes is how to increase efficiency, impact, and coverage. The campaign is based on five Cs:. The multi-pronged strategy shows that a health issue like malnutrition can be tackled with the help of behviour change communication BCC and other social aspects.
This Fund provides support to the voluntary organisations that help the welfare of kids. India is a signatory to the 27 survival and development goals laid down by the World Summit on children These goals have been integrated into National Development Plans. India is associated with UNICEF since and is now in the fifth decade of cooperation for assisting most disadvantaged children and their mothers.
The board has 3 regular sessions and one annual session in a year. A meeting of Government of India and UNICEF officials was concurred on 12 November to finalise the strategy and areas for programme of cooperation for the next Master Plan of operations — which is to synchronise with the Ninth Plan of Government of India. The National Rural Health Mission of India mission was created for the years —, and its goal is to "improve the availability of and access to quality health care by people, especially for those residing in rural areas, the poor, women, and children.
The mission has set up strategies and action plan to meet all of its goals. And a child raised in India is more likely to be malnourished than Somalia. In addition, the air quality in India is among the worst in the world. But now, UNICEF and many charitable organizations are saying that poor sanitation is one of the biggest reasons of malnutrition. But a lot of authorities in India are saying they should change their plan for malnutrition based on sanitation problem.
From Wikipedia, the free encyclopedia. White blood cells are on constant patrol and looking for pathogens. When they find a target, they begin to multiply and send signals out to other cell types to do the same.
Our white blood cells are stored in different places in the body, which are referred to as lymphoid organs. These include the following:. These cells surround and absorb pathogens and break them down, effectively eating them. There are several types, including:.
Lymphocytes help the body to remember previous invaders and recognize them if they come back to attack again. Lymphocytes begin their life in bone marrow. Some stay in the marrow and develop into B lymphocytes B cells , others head to the thymus and become T lymphocytes T cells. These two cell types have different roles:. The immune system needs to be able to tell self from non-self.
It does this by detecting proteins that are found on the surface of all cells. It learns to ignore its own or self proteins at an early stage. In many cases, an antigen is a bacterium, fungus, virus, toxin, or foreign body. But it can also be one of our own cells that is faulty or dead. Initially, a range of cell types works together to recognize the antigen as an invader. Once B lymphocytes spot the antigen, they begin to secrete antibodies antigen is short for "antibody generators".
Antibodies are special proteins that lock on to specific antigens. Each B cell makes one specific antibody. For instance, one might make an antibody against the bacteria that cause pneumonia , and another might recognize the common cold virus. Antibodies are part of a large family of chemicals called immunoglobulins, which play many roles in the immune response:.
Antibodies lock onto the antigen, but they do not kill it, only mark it for death. The killing is the job of other cells, such as phagocytes. Helper T cells Th cells — they coordinate the immune response.
Some communicate with other cells, and some stimulate B cells to produce more antibodies. Others attract more T cells or cell-eating phagocytes. Killer T cells cytotoxic T lymphocytes — as the name suggests, these T cells attack other cells. They are particularly useful for fighting viruses. They work by recognizing small parts of the virus on the outside of infected cells and destroy the infected cells.
Everyone's immune system is different but, as a general rule, it becomes stronger during adulthood as, by this time, we have been exposed to more pathogens and developed more immunity.
Once an antibody has been produced, a copy remains in the body so that if the same antigen appears again, it can be dealt with more quickly. That is why with some diseases, such as chickenpox , you only get it once as the body has a chickenpox antibody stored, ready and waiting to destroy it next time it arrives.
This is called immunity. We are all born with some level of immunity to invaders. Human immune systems, similarly to those of many animals, will attack foreign invaders from day one. This innate immunity includes the external barriers of our body — the first line of defense against pathogens — such as the skin and mucous membranes of the throat and gut.
This response is more general and non-specific. If the pathogen manages to dodge the innate immune system, adaptive or acquired immunity kicks in.
This protect from pathogens develops as we go through life. As we are exposed to diseases or get vaccinated, we build up a library of antibodies to different pathogens. Dose-response trial of prophylactic zinc supplements, with or without copper, in young Ecuadorian children at risk of zinc deficiency. Am J Clin Nutr ;87 3: The effects of zinc supplementation to Chinese rural pregnant women and their pregnancy outcome.
Journal of Shanghai Second Medical University ;13 2: Evaluation of oral zinc sulfate effect on recalcitrant multiple viral warts: Preventive zinc supplementation in developing countries: Public Health ;11 Suppl 3: Intrauterine growth restriction and zinc concentrations in term infants during the first month of life.
A double-blind study of the therapeutic efficacy of zinc gluconate on taste disorder. Auris Nasus Larynx ;18 2: Treatment of Wilson's disease with zinc: J Lab Clin Med ; 3: Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: Int Health ;16 Effects of zinc in chronic hemodialysis.
Zinc transport in pregnancy. Zinc lozenges reduce the duration of common cold symptoms. Accessed 11 November Taste acuity and zinc metabolism in captopril-treated hypertensive male patients. Am J Hypertens ;1: Zinc tolerance test in uremia: J Am Coll Nutr ;7: Zinc absorption from a low-phytic acid maize. Am J Clin Nutr ; A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss.
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: Potential public health impact of age-related eye disease study results: Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: Studies on zinc in wound healing.
Acta Derm Venereol Suppl Stockh ; Interaction of riboflavin with zinc bioavailability. Ann NY Acad Sci ; Efficacy of combination therapy of oral zinc sulfate with imiquimod, podophyllin or cryotherapy in the treatment of vulvar warts.
J Obstet Gynaecol Res. Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: What is the clinical significance of reduced manganese and zinc levels in treated epileptic patients? Med J Australia ; Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. J Antimicrob Chemother ; Intranasal zinc and anosmia: Effects of an EDTA infusion on the urinary elimination of several elements in healthy subjects.
Br J Clin Pharmacol ; Serum and hair zinc levels in epileptic children taking valproic acid. Biol Trace Element Res ;58; Serum zinc in acne vulgaris. Int J Dermatol ; American Academy of Pediatrics Committee on Drugs. Treatment guidelines for lead exposure in children. Zinc acetate treatment in Wilson's disease. Zinc Against Plasmodium Study Group. Effect of zinc on the treatment of Plasmodium falciparum malaria in children: Zinc tolerance tests in chronic aremia.
Reversal of uraemic impotence by zinc. Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: Arens M, Travis S. Zinc salts inactivate clinical isolates of herpes simplex virus in vitro. J Clin Microbiol ; Gamma-linolenic acid for attention-deficit hyperactivity disorder: Placebo-controlled comparison to D-amphetamine.
Int J Neurosci ; Zinc and senile osteoporosis. J Am Geriatr Soc ; A pilot trial using topical regular crystalline insulin vs. Impact on quality of life. Urinary zinc excretion and zinc status of patients with beta-thalassemia major.
Biol Trace Elem Res ; Effects of supplement therapy on sperm parameters, protamine content and acrosomal integrity of varicocelectomized subjects. J Assist Reprod Genet. Randomized, double-blind trial of mg zinc sulfate twice daily in the treatment of rosacea. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: Barak S, Katz J. The effect of Breezy candy on halitosis: J Toxicol Clin Toxicol ; A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children.
Relationships between serum free fatty acids and zinc, and attention deficit hyperactivity disorder: J Child Psychol Psychiatry ; A randomized trial of zinc nasal spray for the treatment of upper respiratory illness in adults.
Am J Med ; Growth velocity monitoring of the efficacy of different therapeutic protocols in a group of thalassaemic children. Eur J Pediatr ; Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: Intensive Care Med ; Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients. Trace element supplementation modulates pulmonary infection rates after major burns: Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine.
Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 years: Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: Nutritional effects of oral zinc supplementation in cirrhosis. Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder.
Prog Neuropsychopharmacol Biol Psychiatry ; Controlled trial of zinc supplementation in anorexia nervosa. Int J Eat Disord ; Zinc and immune function in Down's syndrome. Acta Paediatr Scand ; Expanded activity and utility of the new fluoroquinolones: Short-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: Antioxidant supplement and long-term reduction of recurrent adenomas of the large bowel.
A double-blind randomized trial. J Gastroenterol ;48 6: Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men. Br J Nutr ; Bullous lesions in acrodermatitis enteropathica. Histopathologic findings regarding two patients.
Am J Dermatopathol ; Zinc-induced copper deficiency in an infant. Am J Dis Child ; XV long-term follow-up studies. J Lab Clin Med ; Studies of the effect of zinc on lymphocyte function.
Interaction with other anticopper agents. J Am Coll Nutr ; Topical treatment of recurrent herpes simplex and post-herpetic erythema multiforme with low concentrations of zinc sulphate solution. Br J Dermatol ; Absence of a therapeutic effect of zinc in the sexual dysfunction of haemodialysed patients Lancet ;2: Zinc for severe pneumonia in very young children: A reversible cause of sideroblastic anemia and bone marrow depression.
Morphological study of the effects of intranasal zinc sulfate irrigation on the mouse olfactory epithelium and olfactory bulb. Microsc Res Tech ; Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. A trial of oral zinc supplementation in psoriasis. Zinc concentration in plasma and erythrocytes of subjects receiving folic acid supplementation.
Zinc aspartate, biotin, and clobetasol propionate in the treatment of alopecia areata in childhood. Ethambutol and the eye: Continuous desferrioxamine infusion by an infusor in thalassemia major. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol ; Zinc and glycemic control: J Trace Elem Med Biol. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med ; A systematic review and meta-analysis of the use of oral zinc in the treatment of hepatic encephalopathy.
Genetic testing in persons with age-related macular degeneration and the use of the AREDS supplements: Comparison of zinc concentrations in blood and seminal plasma and the various sperm parameters between fertile and infertile men.
Effects of oral ethinyl oestradiol and norethisterone on plasma copper and zinc complexes in post-menopausal women. Hormone Metab Res ; Zinc supplementation might potentiate the effect of vitamin A in restoring night vision in pregnant Nepalese women.
Psoriatic arthritis treated with oral zinc sulphate. Cohanim M, Yendt ER. The effects of thiazides on serum and urinary zinc in patients with renal calculi. Johns Hopkins Med J ; Zinc supplementation in children and adolescents with acute leukemia. Eur J Clin Nutr. Kinetics of copper absorption in zinc-overload states and following the withdrawal of zinc supplement: Inorganic zinc and the intestinal absorption of ferrous iron. Hyperzincuria in individuals with insulin-dependent diabetes mellitus: Efficacy of different mouthrinse formulations in reducing oral malodour: Serum levels of trace metals in children with atopic eczema.
Zinc absorption in adult humans: The incidence of optic neuropathy in 84 patients treated with ethambutol.
Metab Pediatr Syst Ophthalmol ; Anosmia due to inhalational zinc: Lessons learned from attempts to establish the blind in placebo-controlled trials of zinc for the common cold. Ann Intern Med ; Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children. The effect of staggered administration of zinc sulfate on the pharmacokinetics of oral cephalexin.
Br J Clin Pharmacol. Biochemical and clinical changes occurring during the treatment of rheumatoid arthritis with novel antirheumatoid drugs. Int J Clin Pharmacol Res ;5: Supplemental zinc lowers measures of iron status in young women with low iron reserves.
FDA warns against use of Zicam. The Wall Street Journal, June 16, Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother ; Experimental basis for increasing the therapeutic index of cis-diamminedicarboxylatocyclobutaneplatinum II in brain tumor therapy by a high-zinc diet.
Cancer Chemother Pharmacol ; Low doses of zinc gluconate for inflammatory acne. Acta Derm Venereol ; Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. Zinc in ulcerative colitis: Recovery following peripheral destruction of olfactory neurons in young and adult mice.
Eur J Neurosci ; Bioavailability of orally administered zinc, using Taurizine. Pharm Weekbl Sci ;8: Oral zinc sulphate in alopacia areata- a double-blind trial. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study.
Use of topical zinc to prevent recurrent herpes simplex infection: Zinc ion availability--the determinant of efficacy in zinc lozenge treatment of common colds. Serum zinc levels in corticosteroid-treated asthmatic patients.
Postgrad Med J ; Failure of oral zinc supplementation in atopic eczema. Eur J Clin Nutr ; Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial. Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds.
Double-blind, randomized, controlled trial of zinc or vitamin A supplementation in young children with acute diarrhea. Treatment of valproate-induced alopecia letter. Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: Trial of zinc supplements in relation to pregnancy outcomes, hematologic indicators, and T cell counts among HIVinfected women in Tanzania.
Topical erythromycin with zinc in acne. A double-blind controlled study. J Am Acad Dermatol ;3: Vitamin D-sensitive and quinacrine-sensitive zinc transport in human intestinal cell line Caco Am J Physiol ; Rapid serum zinc depletion associated with corticosteroid therapy. Food and Nutrition Board, Institute of Medicine. National Academy Press, The effect of zinc and vitamin A supplementation on immune response in an older population. Actions and interactions of thyroid hormone and zinc status in growing rats.
Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. The healing of gastric ulcers by zinc sulphate. Med J Aust ;2: High folate intakes related to zinc status in preterm infants. Zinc supplementation improves bone density in patients with thalassemia: Am J Clin Nutr. Relationship between zinc concentrations in seminal plasma and various sperm parameters.
Int Urol Nephrol ; Zinc acexamate vs famotidine in the treatment of acute duodenal ulcer. Study group of zinc acexamate]. Rev Esp Enferm Dig ; Dietary interventions to prevent zinc deficiency. A historical review of progress in the assessment of dietary zinc intake as an indicator of population zinc status.
Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: Arch Intern Med ; Effect of micronutrient supplementation on infection in institutionalized elderly subjects: Ann Nutr Metab ; Altern Ther Health Med ;7: Zinc gluconate and the common cold: J Int Med Res ; Gogia S, Sachdev HS. Zinc supplementation for mental and motor development in children. Cochrane Database Syst Rev. The effect of zinc supplementation on pregnancy outcome.
Effect of the administration of zinc sulfate on hypogonadism and impotence in patients with chronic stable hepatic cirrhosis. J Am Coll Nutr ;2: Zinc metabolism in patients treated with captopril versus enalapril. Hydrochlorothiazide-amiloride causes excessive urinary zinc excretion. Clin Pharmacol Ther ; Effects of captopril and enalapril on zinc metabolism in hypertensive patients. The efficacy of zinc for treatment of chronic prostatitis. Oral zinc in acne vulgaris: Zinc and the eye. The effect of zinc supplementation on parasitic reinfestation of Guatemalan schoolchildren.
Mucocutaneous pigmented macule as a result of zinc deposition. J Cutan Pathol ; Guide to Clinical Preventive Services. Natl Institute of Health, Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production.
Prostaglandins Leukot Essent Fatty Acids ; Metal excretion and magnesium retention in patients with intermittent claudication treated with intravenous disodium EDTA. Zinc therapy in dermatology: Efficacy of zinc therapy in prevention of crisis in sickle cell anemia: J Assoc Physicians India ; Absorption of trace metals in the zinc-deficient rat.
Drug Interactions Analysis and Management. Chemistry of dexrazoxane and analogues. Association of long-term, excessive use of zinc-containing Poli-Grip products with myeloneuropathy and blood dyscrasias.
Drug Facts and Comparisons. Facts and Comparisons, Zinc acetate lozenges for treating the common cold: Effect of intragastric pH on the absorption of oral zinc acetate and zinc oxide in young healthy volunteers.
Relevance of zinc in human sperm flagella and its relation to motility. Zinc metabolism in adrenal cortical insufficiency: Am J Med Sci ; Efficacy of exogenous oral zinc in treatment of patients with carbonic anhydrase VI deficiency. A double-blind study of the effects of zinc sulfate on taste and smell dysfunction. Zinc deficiency and taste disorders. Serum zinc and vitamin E concentrations in handicapped children treated with anticonvulsants. Devel Pharmacol Ther ;5: Trace element homeostasis during continuous sedation with propofol containing EDTA versus other sedatives in critically ill patients.
Comparison of oral treatment with zinc sulphate and placebo in acne vulgaris. Zinc and copper concentrations in leukocytes and erythrocytes in healthy adults and the effect of oral contraceptives. J Clin Pathol ; Zinc nasal gel for the treatment of common cold symptoms: A double-blind, placebo-controlled trial.
Ear Nose Throat J ; Management of Wilson's disease with zinc sulphate. Experience in a series of 27 patients. J Neurol Sci ; Successful treatment of four patients with recalcitrant vaginal trichomoniasis with a combination of zinc sulfate douche and metronidazole therapy. Sex Transm Dis ; Alzheimer's disease, beta-amyloid protein and zinc.
Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young men. Moving toward a plant-based diet; are iron and zinc at risk? Selenium, zinc, and copper changes with valproic acid: Valproate, birth defects, and zinc letter.
Influence of vegetable protein sources on trace element and mineral bioavailability. Zinc intakes and plasma concentrations in men with osteoporosis: Serum and hair trace element levels in patients with epilepsy and healthy subjects: Eur J Neurol ;6: Effect of zinc supplementation on vitamin status of middle-aged and older European adults: J Clin Nutr ;62 Zinc and the common cold: Dietary supplement interactions with antiretrovirals: Effects of zinc supplementation on endocrine outcomes in women with polycystic ovary syndrome: Biol Trace Elem Res.
Meta-analysis of efficacy of zinc acexamate in peptic ulcer. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J Pineal Res ; Serum copper and zinc levels in epileptic children with valproate treatment. Kakar F, Henderson MM. Potential toxic side effects of folic acid letter. J Natl Cancer Inst ; Zinc supplementation and the effects on metabolic status in gestational diabetes: A randomized, double-blind, placebo-controlled trial.
Zinc supplementation and the effects on pregnancy outcomes in gestational diabetes: Exp Clin Endocrinol Diabetes. Zinc deficiency in anorexia nervosa. J Adolesc Health Care ;8: Zinc status is not adversely affected by folic acid supplementation and zinc intake does not impair folate utilization in human subjects. Necrolytic acral erythema associated with hepatitis C effective treatment with interferon alfa and zinc. Zinc, hydrochlorothiazide and sexual dysfunction. Cent Afr J Med ; Zinc and chronic renal disease.
Seminar in Dialysis ;2 4: King AB, Schwartz R. Effects of the antituberculous drug ethambutol on zinc absorption, turnover and distribution in rats fed diets marginal and adequate in zinc. Do women using oral contraceptive agents require extra zinc? Enhanced zinc utilization during lactation may reduce maternal and infant zinc depletion. Zinc deficiency following penicillamine therapy. Trace Elements in Human Health and Disease.
I, Zinc and Copper. Academic Press, New York, Fatty acid composition of plasma lipids in acrodermatitis enteropathica before and after zinc supplementation. Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein. Cadmium in zinc-containing mineral supplements. Int J Food Sci Nutr ; Zinc supplementation for neonatal hyperbilirubinemia: Dietary flavonoids interact with trace metals and affect metallothionein level in human intestinal cells.
Diet and benign prostatic hyperplasia: Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Urinary magnesium and zinc excretion after two different single doses of amiloride in healthy adults. Effect of zinc therapy on neutrophil chemotaxis in psoriasis. Isr J Med Sci ; Leibovitz B, Siegel BV. Ascorbic acid and the immune response.
Adv Exp Med Biol ; Zinc supplement use and risk of prostate cancer. Plasma zinc status, growth, and maturation in children with sickle cell disease. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Cutaneous manifestations of zinc deficiency during treatment with anticonvulsants.